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Updated: Feb 20, 2026

ATAC-Seq Library Preparation of Murine Bone Marrow-Derived Neutrophils
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Znf711-Phf8複合体は,中性粒子の発達に不可欠な転写性レオスタットとして機能する

Shuiyi Tan1, Huihui Qian2, Haihong Wang2

  • 1Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; CNRS IRP (International research Project), Cancer, Aging and Hematology, Sino-French Research Center for Life Sciences and Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Department of Hematology, Huashan Hospital, Fudan University, Shanghai 200040.

Haematologica
|February 19, 2026
PubMed
まとめ

以前,転写を活性化すると考えられていたZnf711-Phf8複合体は,実際には中性粒子の発育を抑制します. この発見は,中性粒子がどのように成熟するかを制御する新しいメカニズムを明らかにしています.

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