2型糖尿病の認知機能,脳構造,機能に対する血清プロラクチンの影響

Xiang Xu^1,2, Huijie Yang^1,2, Congcong Yu^2,3

¹Department of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.

The Journal of clinical endocrinology and metabolism

|February 19, 2026

まとめ

2型糖尿病患者の低プロラクチン (PRL) レベルは,認知機能低下と脳の変化と関連しています. これは,PRLが糖尿病に関連した認知機能不全に役割を果たす可能性があることを示唆しています.

科学分野:

神経内分泌学の神経内分泌学
メタボリック障害メタボリック障害
認知神経科学は,認知神経科学である.

背景:

糖尿病関連認知機能不全 (DACD) は,代謝および神経機能不全を含む.
pituitaryホルモンであるプロラクチン (PRL) は,グルコース調節と神経炎症に影響を与え,DACDに潜在的に貢献します.

研究の目的:

2型糖尿病 (T2DM) の血清プロラクチン (PRL) と認知機能の関係を調査する.
PRLとT2DM患者における認知障害を結びつける神経イメージングメカニズムを調査する.

主な方法:

1167人のT2DM患者 (522人の認知能力は正常で,418人の認知障害は軽度) を分析した.
機能性磁気共鳴画像 (fMRI) は,247人の参加者の脳構造と機能を評価した.
構造方程式モデリング (SEM) は,血清PRLと認知を結びつけるメカニズムを探索しました.

主要な成果:

血清PRLは,T2DMにおけるMCIの独立した危険因子でした.
低PRLレベルは,海馬と桃体の体積の減少と相関する.
桃体と前頭葉の機能的接続性の低下は,最も低いPRL群で観察されました.

結論:

血清PRLの減少は,T2DMにおける認知能力の低下と関連しています.
PRLの低いレベルは,海馬-桃体体量の減少と桃体の接続性の障害を含む脳の構造的および機能的な変化と相関しています.
PRLは,T2DM患者のリンビック構造を通して間接的に認知に影響を与えます.

キーワード:

プロラクチンはプロラクチンです.アミグダラ・アミグダラとは機能的な接続性である.ヒポカンプス (海馬)軽度の認知機能障害である.2型糖尿病メリートゥス

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