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Updated: Feb 20, 2026

Establishing 3-Dimensional Spheroids from Patient-Derived Tumor Samples and Evaluating their Sensitivity to Drugs
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Establishing 3-Dimensional Spheroids from Patient-Derived Tumor Samples and Evaluating their Sensitivity to Drugs

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ER陽性乳がんにおけるパルボシクリブに対する多層次分子応答の図表

Archishma Kavalipati1,2, Amy Aponte2, Michael E Sullivan2

  • 1Curriculum in Bioinformatics and Computational Biology, University of North Carolina, Chapel Hill, NC 27599, United States.

NAR cancer
|February 19, 2026
PubMed
まとめ

CDK4/6阻害剤は乳がんの治療を改善しますが,抵抗に直面します. この研究は,複雑な分子変化とフィードバックループを明らかにし,CDKとエストロゲン受容体経路を標的とした新しい組み合わせ治療法を提案し,より高い有効性を示しています.

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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

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Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
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