関連する実験動画

Updated: Feb 20, 2026

A Proteoliposome-Based Efflux Assay to Determine Single-molecule Properties of Cl- Channels and Transporters
07:47

A Proteoliposome-Based Efflux Assay to Determine Single-molecule Properties of Cl- Channels and Transporters

Published on: April 20, 2015

10.4K

グルタチオンで活性化可能な合成チャネルで,ジャンプ媒介アニオン輸送を行う

Sandip Chattopadhayay1, Debraj Ganguly1, Triveni Sodnawar2

  • 1Department of Chemistry, Indian Institute of Science Education and Research Pune Dr Homi Bhabha Road, Pashan Pune 411008 Maharashtra India ptalukdar@iiserpune.ac.in.

Chemical science
|February 19, 2026
PubMed
まとめ

研究者らは,グルタチオンの活性化により安定したアニオンチャネルを形成する合成イオントランスポーターを開発した. これらのチャネルは,天然の細胞過程を模倣して,アンチポートメカニズムを介して,クロライドイオンを膜に選択的に輸送します.

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Secondary Active Transport

One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme "pump" embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
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Certain large, lipid-insoluble drug molecules that resemble amino acids, peptides, or glucose, require specialized carrier proteins to facilitate their diffusion across cell membranes. This transport can occur through either facilitated diffusion, which does not require energy input, or active transport, which does require energy input.
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Glutathione, a tripeptide made up of glutamate, cysteine, and glycine, is a critical player in the detoxification of drugs and xenobiotics via a process known as glutathione conjugation or mercapturic acid formation. This phase II biotransformation reaction involves the covalent binding of glutathione to a drug or its metabolite, enhancing the compound's water solubility and enabling its excretion.
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