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Updated: Feb 20, 2026

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
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精密がん治療のためのPithecellobium dulceからのアイソフォーム選択性AKT阻害剤の薬物遺伝学およびシリコイン識別

Gnanaprakash Jeyaraj1, Bing Yang2, Kuppusamy Sathishkumar3

  • 1Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.

Frontiers in pharmacology
|February 19, 2026
PubMed
まとめ

この研究では,選択的にAKT1およびAKT2キナーゼを標的にするPithecellobium dulceからの天然化合物であるオレアノール酸とルチンを特定しました. これらの発見は,PI3K-AKT-mTOR経路を標的とした新しい精密腫瘍学療法を開発するための基盤を提供します.

キーワード:
AKT1/AKT2を阻害する.ピテセルロビウム・ドゥルケス (Pithecellobium dulce) とは,この種の植物に属している.アイソフォームの選択性分子ダイナミクス 分子ダイナミクス自然製品 薬剤の発見

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