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Updated: Feb 20, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

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アミドを1,2,3-トリアゾールでバイオアイソステリックに置き換えると,ドーパミンD4受容体リガンドの薬理学が改善される

Mohammad Alkhatib1, Franziska M Jakobs2, John N Hanson3

  • 1Department of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.

ACS pharmacology & translational science
|February 19, 2026
PubMed
まとめ

トライアゾールリンカーを使用した新しいドーパミンD4受容体 (D4R) リガンドは,マウスの代謝安定性と脳曝露の改善を示しています. これらの化合物は,神経学的プロセスにおけるD4Rシグナル伝達の研究に役立つツールです.

キーワード:
1,2,3-トリアゾール 1,2,3-トリアゾールアゴニストアゴニストアンタゴニスト・アンタゴニスト.バイオ・アイソステリアは,バイオ・アイソステリアである.ドーパミンD4受容体についてファルマコキネティクス 薬理学

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