関連する実験動画

Updated: Feb 20, 2026

Extracting the Young's Modulus of Native Murine Pulmonary Basement Membranes from Atomic Force Microscopy Derived Force Maps
10:55

Extracting the Young's Modulus of Native Murine Pulmonary Basement Membranes from Atomic Force Microscopy Derived Force Maps

Published on: January 31, 2025

970

初期の骨関節炎における重要な分子イベントとしての細胞外マトリックス硬化:RhoA/ROCKとERK1/2経路の交差点

Kai Huang1, Haili Cai2, Yifan Hong3

  • 1Tongde Hospital of Zhejiang Province, Hangzhou, China.

The American journal of sports medicine
|February 19, 2026
PubMed
まとめ

骨格関節炎における細胞外マトリックス (ECM) の硬化により,RhoA/ROCKシグナリングが活性化され,その後ERK1/2シグナリングが活性化され,軟骨の劣化が促進されます. SPRY-4は,この経路を調節し,初期のOAに対する潜在的な治療標的を提供します.

キーワード:
ERK1/2についてRhoA/ROCK についてSPRY-4は,SPRY-4に該当する.コンドロサイト (chondrocytes) とは細胞外マトリックス硬さ骨格関節炎 (Osteoarthritis) とは,骨格関節炎 (Osteoarthritis) とは,骨格関節炎 (Osteoarthritis) とは,骨格関節炎 (Osteoarthritis) とは,

さらに関連する動画

A Multi-well Format Polyacrylamide-based Assay for Studying the Effect of Extracellular Matrix Stiffness on the Bacterial Infection of Adherent Cells11:51

A Multi-well Format Polyacrylamide-based Assay for Studying the Effect of Extracellular Matrix Stiffness on the Bacterial Infection of Adherent Cells

Published on: July 5, 2018

12.3K
Studying the Effects of Matrix Stiffness on Cellular Function using Acrylamide-based Hydrogels10:19

Studying the Effects of Matrix Stiffness on Cellular Function using Acrylamide-based Hydrogels

Published on: August 10, 2010

22.8K

関連する概念動画

Extracellular Matrix01:26

Extracellular Matrix

Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
5.9K
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
3.6K
The Extracellular Matrix01:29

The Extracellular Matrix

Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
12.6K
The Extracellular Matrix01:42

The Extracellular Matrix

Overview
89.8K
Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
3.5K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
13.2K