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Updated: Jul 27, 2026

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血液学的悪性腫瘍における変異シグネチャー

Felipe de Almeida Sartori1,2, João Vitor Paes Pontes2, Paulo Vidal Campregher2,3

  • 1Case Western Reserve University, Cleveland, Ohio, United States.

Einstein (Sao Paulo, Brazil)
|February 19, 2026
PubMed
まとめ

腫瘍における体的変異は,様々なプロセスから生じる異なった変異のサインを明らかにする. 血液学的癌におけるこれらのサインを分析することで,癌の原因と個別化された治療戦略の洞察が得られます.

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...