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Updated: Feb 21, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

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進行性乳がんにおける第一線対第二線CDK4/6阻害剤の全生存率:ランダム化臨床試験

Noor Wortelboer1, Annemiek van Ommen-Nijhof2, Inge R Konings3

  • 1Department of Medical Oncology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands.

JAMA oncology
|February 19, 2026
PubMed
まとめ

ファーストラインのサイクリン依存キナーゼ4およびキナーゼ6阻害剤 (CDK4/6i) は,セカンドライン使用と比較して,進行性乳がんにおける全生存率を向上させなかった. しかし,ファーストラインのCDK4/6iは,閉経前患者における生存効果と,有毒性の増加を示した.

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