妊娠中の代謝機能障害に関連したステアトス性肝疾患:レビュー
Daniel Core1, Layne Landry1, Christopher Menefee1
1Resident, Department of OBGYN.
Obstetrical & gynecological survey
|February 19, 2026
まとめ
代謝機能障害に関連するステアトス性肝疾患 (MASLD) は,妊娠中に一般的であり,有害な結果に関連しています. 早期発見と管理は,母と乳児の健康にとって極めて重要です.
科学分野:
- 肝臓病理学 肝臓病理学
- 妊産婦・胎児医学について
- メタボリック障害 メタボリック障害
背景:
- メタボリック機能障害に関連した脂肪性肝疾患 (MASLD),以前は非アルコール性脂肪性肝疾患であったが,妊娠中の14%が罹患している.
- MASLDは,肥満やインスリン抵抗性などの代謝併発症と関連しています.
- 妊娠中の合併症,妊娠糖尿病,高血圧疾患などに関連しています.
研究 の 目的:
- MASLD.の病理生理学,診断,管理,および妊娠合併症の見直しをすること.
- 妊婦の集団におけるMASLDの増加傾向と診断不足を強調する.
主な方法:
- Rayyan. を使って文献検索が行われました.
- 2000年から2024年の間に出版された180件の記事をレビューしました.
主要な成果:
- MASLDは増加傾向にあり,妊娠中に診断が不十分である可能性が高い.
- 肥満と妊娠の生理学的変化は,肝臓ステアトーシスを悪化させる可能性があります.
- MASLDは,妊娠と子孫の不良の結果と関連しています.
結論:
- 妊娠中のMASLDの最適なスクリーニング,診断,管理のためにさらなる研究が必要です.
- 早期発見は,糖尿病のスクリーニングと低用量アスピリンの必要性を保証するかもしれません.
- 妊産婦の死亡率,早産,子代謝疾患などのリスクに関するカウンセリングは不可欠です.
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