地方のワクチン接種率を評価するためのサンプリングアプローチを比較する:中央アフリカ共和国とコンゴ民主共和国でのパイロット研究
Jean-Bosco N Kasonga1, Nicole A Hoff2, Sydney Merritt2
1Kinshasa School of Public Health, University of Kinshasa, Kinshasa, the Democratic Republic of the Congo.
Vaccine
|February 19, 2026
まとめ
GISとKSPH-VCSを含むワクチン接種率調査のための代替サンプリングアプローチは,地域レベルでのモニタリングに希望を示しており,WHOの基準に適した選択肢を提供しており,特に集約された見積もりの場合です.
科学分野:
- 公衆衛生は公衆衛生である.
- エピデミオロジー エピデミオロジー
- 調査方法論 調査方法論
背景:
- ワクチン接種率調査 (VCS) は,予防接種プログラムの監視に不可欠であり,特に信頼性の低い行政データを持つ地域では特に重要です.
- 地区レベルのワクチン接種データは限られており,その重要性にもかかわらず,地方計画と公平性の監視を妨げています.
- 世界保健機関 (WHO) のワクチン接種対象群集調査 (WHO-VCCS) は標準ですが,地区レベルの精度のために代替方法が必要です.
研究 の 目的:
- 3つの代替サンプリングアプローチ (ASA) の有効性と精度を,WHO-VCCSと健康地区レベルで比較する.
- キンシャサ公衆衛生学校VCS (KSPH-VCS),地理情報システム (GIS) ベースのサンプリング,およびロット品質保証サンプリング (LQAS) のパフォーマンスを評価する.
- これらのASAの有用性を,地区別および集約 (地域/国家) ワクチン接種推定値の両方に評価する.
主な方法:
- 中央アフリカ共和国とコンゴ民主共和国の5つの保健区 (都市と農村) で,横断的な研究が行われました.
- 4つのサンプリングアプローチ (WHO-VCCS,KSPH-VCS,GISベースの,LQAS) が同時に適用され,12〜23ヶ月の子供に対する17のワクチン接種指標のデータを収集しました.
- 比較は絶対差,信頼区間含有,CI幅比,WHOCI以外の推定値の割合を用いて行われ,ロジスティック回帰,DEFF,ICCも分析された.
主要な成果:
- GISベースのサンプリングでは,WHO-VCCSとの一致度が最も高い (5 pp.以内の49.3%) ことが示されました. 幅の差は大きいが,信頼区間は最も広い (幅の平均比: 2.2).
- KSPH-VCSは,より狭いCI (平均幅比1.7) と中等な有効性 (5 pp.内の22.4%) とのバランスを提供しました. 差異 (差異) とは
- LQASは,WHO CIs以外の推定値の割合が最も高かった (中位数:18.5 pp.). KSPH-VCSとGISは統計的にWHO-VCCSと5つの地区のうち3つの地区で比較可能であり,LQASは4つの地区で比較可能であった. すべてのASAは,集約されたレベルで同様のパフォーマンスを示しました.
結論:
- KSPH-VCSとGISベースのサンプリングは,地域レベルでのワクチン接種率モニタリングのためのWHO-VCCSの実行可能な代替手段であり,特に受け入れ可能な精度で集約された見積もりを生成するためのものです.
- GISは高度なコンコンダンスを提供していますが,より広範なCIsは精度要件を考慮する必要があります.
- これらの代替サンプリングのアプローチのコスト,実現可能性,適応性をさまざまな環境で評価するために,さらなる研究が推奨されています.
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