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Updated: Jun 27, 2026

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
05:33

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

リソソームを標的とするキメラは,標的タンパク質の分解を可能にします

Bozhao Li1, Yanyan Li2, Jian Zhang3

  • 1Institutes of Biomedical Sciences, Inner Mongolia University, Hohhot 010070, China; Institute of Nanotechnology and Intelligence (inAI), Jinan University, Guangzhou 510632, China.

Cell chemical biology
|February 19, 2026
PubMed
まとめ

リソソームを標的とするキメラ (LYTACs) は,治療上の利益のために細胞外タンパク質を分解する新しい方法を提供します. このレビューでは,LYTACのメカニズム,受容体の関与,そして次世代医薬品開発における課題について詳細に説明します.

キーワード:
LYTACs (ライトカス) とは細胞外タンパク質の分解ライソソームを標的とするキメラ.受容体媒介性エンドサイトーシスは受容体媒介性エンドサイトーシスです.標的となるタンパク質の分解を狙った.

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