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Bifidobacterium infantisとB. longumのゲノムアトラスは,乳児のプロバイオティクスの設計について情報を提供します
Yan Shao1, Shuyi Wang1, Bonface M Gichuki2
1Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK.
Cell
|February 19, 2026
まとめ
Bifidobacterium longumやB. infantisのような商用プロバイオティック菌株は,すべての乳児にとって最適ではないかもしれません. グローバルゲノムアトラスは,B. infantisが低所得国において一般的であることを明らかにし,地理的に適したプロバイオティクスが必要であることを示唆しています.
科学分野:
- マイクロバイオームの研究
- ゲノミクスゲノミクスとは
- プロバイオティクス プロバイオティクス
背景:
- Bifidobacterium longumとB. infantisは,重要な早期腸内コロニザーであり,一般的なプロバイオティクスです.
- 現在の商業用プロバイオティックは,しばしば高所得国 (HICs) から由来し,低・中所得国 (LMICs) の乳児には適さない場合があります.
研究 の 目的:
- Bifidobacterium種の包括的なグローバルなゲノムアトラスを作成する.
- B. longumとB. infantisのゲノム多様性と地理的分布を調査する.
- 地理的に適切なプロバイオティクスの菌株の開発を促す.
主な方法:
- 48カ国から4000以上のビフィドバクテリアのゲノムを組み立てました.
- 高解像度の系統遺伝学および機能分析.
- 比較ゲノミクスは,地元の食事と環境への適応を特定します.
主要な成果:
- B. longumとB. infantisは,異なる機能と有病率を持つ異なる種として確認されています.
- B. infantisはLMICの生命の初期微生物群に多く見られるが,HICでは稀である.
- 自然のB. infantis菌株は,地理的層分化と,地元の食事と母乳成分への適応が顕著である.
結論:
- Bifidobacteriumの世界的なゲノムリソースが確立されており,LMICsからの代表が増加しています.
- B. infantisの地理的多様性は,場所固有のプロバイオティクスの選択の必要性を示唆しています.
- このリソースは,多様な乳児集団のための精密プロバイオティクスと微生物群の治療法の開発を導くことができます.
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