調

Yuanhao Wang1, Yuhan Wang1, Wenjie Yuan1

  • 1Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Cell
|February 19, 2026
PubMed
まとめ

ヒスティジンスキャンにより,T細胞受容体 (TCR) ホットスポットが特定され,キャッチボンド形成が強化されます. これにより,毒性のない固体腫瘍に対するより安全なTCR-T細胞療法のための強力な低親和性TCRの設計が可能になります.

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