抗精神病薬の好み:大規模な調査
Babet N Wezenberg1, Jara Bouws1,2, Marieke van der Pluijm1,2
1Department of Psychiatry, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands.
Pharmacopsychiatry
|February 19, 2026
まとめ
抗精神病薬に対する患者の好みは大きく異なります. 望ましい症状の有効性と許容可能な副作用を含む,これらの個々のニーズを理解することは,治療の遵守と共有された意思決定への信頼を改善するために不可欠です.
科学分野:
- 精神科医は精神病を患っている.
- 薬理学 薬理学とは
- 患者中心のケア
背景:
- 抗精神病薬は精神病障害の治療に不可欠です.
- これらの薬に対する個々の患者の好みに関する大規模な研究は稀である.
- 患者の視点を理解することは,治療結果を最適化するための鍵です.
研究 の 目的:
- 抗精神病薬の治療に対する患者の視点の違いを探求する.
- 効果,副作用,投与経路に関する患者の好みに影響する重要な要因を特定する.
- これらの好みにおける人口統計学的および薬剤関連の差異を調査する.
主な方法:
- 精神病エピソードを患った8743人の個人から,オンラインのパーソナル・アンチ精神病選択指数アンケートを使用して収集されたデータです.
- 治療の有効性,副作用,投与経路に関する評価された好み.
- 非パラメトリックテストを用いて反応を分析し,性別,年齢,薬剤のD2受容体相性により比較した.
主要な成果:
- 精神病症状の有効性は最優先 (75.4%),次に認知 (61.9%) とうつ病 (49.5%) 症状の有効性が挙げられました.
- エクストラピラミッド症状 (73.2%) と体重増加 (68.0%) は,最も受け入れがたい副作用でした.
- 日用錠剤は最も好ましい投与経路 (91.0%) であり,患者の好みは性別,年齢,および薬剤のD2受容体 afinity に基づいて変化しました.
結論:
- 抗精神病薬に対する患者の好みには大きな違いがあります.
- 患者さんの好みを共有した意思決定に組み込むことは,信頼と治療への従順性を高めることができます.
- 個々のニーズに基づく治療の調整は,精神病障害の効果的な管理に不可欠です.
関連する概念動画
Psychosis and Antipsychotic Drugs: Overview
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic symptoms in all...
Psychosis: Goals of Pharmacotherapy
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...
Antipsychotic Drugs: Typical and Atypical Agents
Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
Antipsychotic Drugs: Therapeutic Uses and Side Effects
Antipsychotic drugs primarily block dopamine and serotonin receptors and cholinergic, adrenergic, and histaminergic receptors, thereby reducing hallucinations and delusions in conditions like schizophrenia. However, they can trigger unwanted extrapyramidal effects such as dystonias, Parkinson-like symptoms, and tardive dyskinesia.
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
Antidepressant Drugs: MAOIs and Other Agents
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
Drug Therapy
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications


