因子Vライデン変異を有する患者のIVC症候群
Melissa Postoll-Downs1, Kajal Patel2, John Levasseur3
1Internal Medicine, San Antonio Uniformed Services Health Education Consortium, Joint Base San Antonio Fort Sam Houston, Texas, USA melissa.a.postoll-downs.mil@health.mil.
BMJ case reports
|February 19, 2026
まとめ
大量の血栓がV因子患者で足の激しい腫れと痛みを引き起こした. 治療には,アグラトロバンとフォンダパリヌックスによる血栓除去と抗凝固剤が含まれていました.
科学分野:
- 血管外科 血管外科
- 血液学 ヘマトロジ
- クリティカルケア・メディシン
背景:
- V因子ライデンは,特に外科手術後の血栓形成のリスクを高めます.
- 以前の出血合併症は,抗凝固剤の管理を複雑にしました.
- 急性深静脈栓塞 (DVT) は,重度の肢体イシュケミアにつながる可能性があります.
研究 の 目的:
- ファクターVの患者で発生した,大型の骨頭側頭部深静脈栓塞 (DVT) の症例を報告する.
- 出血合併症の歴のある患者における抗凝固剤の管理上の課題について議論する.
- 血管内凝固除去と代替抗凝固戦略の成功した使用を強調する.
主な方法:
- V Factor Leidenの患者とDVTの既往歴のある患者は,急性線頭頭DVTを発症しました.
- 診断イメージングにはCT静脈撮影とポイント・オブ・ケア・超音波検査が含まれていました.
- 治療には,血管内血栓切除術を施し,その後,アグラトロバンによる抗凝固療法と,フォンダパリヌックスへの移行が施されました.
主要な成果:
- CT画像は,左側陰茎静脈に大規模な閉塞性血栓があることを確認した.
- 超音波検査では,下腔静脈が完全に崩壊し,重度の静脈閉塞を示した.
- 患者は血栓の除去に成功し,治療的抗凝固薬に移行されました.
結論:
- 大規模な iliofemoral DVT は,迅速な介入を必要とする,四肢を脅かす状態です.
- 血管内血栓の除去は,特定のケースでは有効である可能性があります.
- 抗凝固剤の慎重な選択は,出血のリスクのある患者において極めて重要であり,アグラトロバンやフォンダパリヌックスなどの薬剤が代替品を提供している.
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