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関連する概念動画

Porin Insertion in the Outer Mitochondrial Membrane01:12

Porin Insertion in the Outer Mitochondrial Membrane

Porins are beta-barrel proteins translocated to the mitochondrial outer membrane through the TOM complex into the intermembrane space. Porin precursors bind TIM chaperones within the intermembrane space and are guided to the Sorting and Assembly Machinery complex or SAM complex on the outer mitochondrial membrane.
Three models describe the assembly of porins by the SAM complex and their insertion into the outer membrane. Model 1 suggests that porins are assembled outside the SAM channel as the...
pV-Diagrams01:18

pV-Diagrams

The pV diagram, which is a graph of pressure versus volume of the gas under study, is helpful in describing certain aspects of the substance. When the substance behaves like an ideal gas, the ideal gas equation describes the relationship between its pressure and volume. On a pV diagram, it is common to plot an isotherm, which is a curve showing p as a function of V with the number of molecules and the temperature fixed. Then, for an ideal gas, the product of the pressure of the gas and its...
Fluid Pressure over Curved Plate of Constant Width01:12

Fluid Pressure over Curved Plate of Constant Width

When a curved plate of constant width is submerged in a liquid, the pressure acting normal to the plate varies continuously both in magnitude and direction. Calculating the magnitude and location of the resultant force at a point is often challenging for such cases. One of the methods to determine the resultant force and its location involves separately calculating the horizontal and vertical components of the resultant force. This complex calculation can be simplified by representing the...
Fluid Pressure over Flat Plate of Variable Width01:02

Fluid Pressure over Flat Plate of Variable Width

When a flat plate is submerged in a fluid, the fluid exerts pressure on the plate. This pressure can lead to many different phenomena, including drag and buoyancy. To understand the behavior of the fluid over a flat plate of variable width, it is essential to analyze the distribution of the pressure exerted.
The pressure distribution on the plate can be calculated by determining the force that acts on a differential area strip of the plate. Thus, the magnitude of the force is equal to the...
Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

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Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles
09:27

Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles

Published on: August 16, 2012

ペリンドプリル:包括的なプロフィール

Jude Majed Lababidi1, Mohamed Fawzy Kabil1, Hassan Mohamed El-Said Azzazy1

  • 1Department of Chemistry, School of Sciences and Engineering, The American University in Cairo, New Cairo, Egypt.

Profiles of drug substances, excipients, and related methodology
|February 19, 2026
PubMed
まとめ
この要約は機械生成です。

この章では,ペリンドプリルアルギニン (PER-Arg) の性質と,ペリンドプリルアルブミン (PER-E) を定量化するための分析方法について詳細に説明します. これらのACE阻害剤の物理化学的属性,合成,および様々な定量化技術について説明します.

キーワード:
アンジオテンシン変換酵素 (ACE) 阻害剤クロマトグラフィークロマトグラフィー核磁気共鳴による核磁気共鳴は,ペリンドプロリル (Perindopril) とはスペクトロフローロメトリーです.スペクトロフォトメトリースペクトロフォトメトリー熱分析による分析です.紫外線スペクトルのUVスペクトル

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PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions
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PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions

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Platelet-Rich Plasma Lysate for Treatment of Eye Surface Diseases
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Platelet-Rich Plasma Lysate for Treatment of Eye Surface Diseases

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Last Updated: Jun 6, 2026

Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles
09:27

Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles

Published on: August 16, 2012

PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions
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PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions

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科学分野:

  • 製薬化学 製薬化学について
  • アナリティカル・ケミストリー (Analytical Chemistry) とは

背景:

  • ペリンドプリル (PER) は,高血圧および心血管疾患に使用されるアンジオテンシン変換酵素 (ACE) 阻害剤です.
  • 2つの主要塩であるペリンドプリルアルギニン (PER-Arg) とペリンドプリルエルブミン (PER-E) が開発されています.

研究 の 目的:

  • PER-Arg.g.の物理化学的性質の包括的な概要を提供するために.
  • PER-ArgとPER-Eを定量化するための分析方法論について議論する.

主な方法:

  • PER-Argの物理化学的特徴 (構造,合成,結晶学,熱安定性,UV吸収性) について
  • クロマトグラフィー,スペクトロフォトメトリー,スペクトルフローリメトリー,バイオセンサ,放射性免疫測定を含む定量化方法のレビュー.

主要な成果:

  • PER-Argの詳細な物理化学プロファイルが確立されました.
  • 様々な行列でPER-ArgとPER-Eを定量化するのに適した様々な分析技術について議論されました.

結論:

  • PER-Argの特性を理解することは,その医薬品の適用に不可欠です.
  • PER-ArgとPER-Eの正確な定量化のために,一連の検証された分析方法があります.