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Updated: Feb 21, 2026

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

Published on: January 21, 2020

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スピロインドレーニン経由のポリサイクルインドリンの合成:メカニズム的検証とHDAC6阻害の可能性

Bo-Bo Gou1, Chao-Feng Chong1, Zhi-Yong Lu2

  • 1Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710127, P. R. China.

Organic letters
|February 19, 2026
PubMed
まとめ

研究者らは,機能化されたペンタサイクルのインドリンを合成する新しい方法を開発した. これらの化合物は,HDAC6.6に対する強い結合親和性と安定性により,薬物誘導体としての潜在能力を示しています.

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The Diels–Alder reaction is an example of a thermal pericyclic reaction between a conjugated diene and an alkene or alkyne, commonly referred to as a dienophile. The reaction involves a concerted movement of six π electrons, four from the diene and two from the dienophile, forming an unsaturated six-membered ring. As a result, these reactions are classified as [4+2] cycloadditions.
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