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Updated: May 5, 2026

In Vitro Analysis of PDZ-dependent CFTR Macromolecular Signaling Complexes
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タンパク質ドメイン拡張によるPDZドメインのアロステリックおよびエネルギーリモデリング

Cristina Hidalgo-Carcedo1, Andre J Faure1,2, Aina Martí-Aranda3

  • 1Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.

Nature communications
|February 19, 2026
PubMed
まとめ

タンパク質ドメインの拡張は,タンパク質のエネルギー環境を大幅に変化させ,機能の調節と進化に影響を与えます. これらの変化は,タンパク質の安定性とリガンド結合に影響を及ぼし,アロステリック制御のための新しい可能性を生み出します.

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