関連する実験動画

Updated: Feb 21, 2026

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
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Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation

Published on: August 1, 2018

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ペプチド骨幹の改変のためのアミドからクロロアルケンの置換 膜の透過性を高めるためのペプチド骨幹の改変

Sayuri Takeo1, Mio Takeda2, Chihiro Iio1

  • 1Graduate School of Medical Photonics, Shizuoka University, 3-5-1 Johoku, Hamamatsu 432-8011, Shizuoka, Japan.

Journal of medicinal chemistry
|February 20, 2026
PubMed
まとめ

クロロアルケンの二ペプチドイソステル (CADI) は,従来の方法と比較してペプチド膜の透過性と細胞の吸収を著しく高めます. このバックボーン改変は,リポフィリシティと水分補給を改善し,薬剤設計に役立ちます.

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Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)

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Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.
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Biological membranes are more than just a barrier separating cell cytoplasm from the outside environment. They are highly dynamic and help maintain the integrity and physiological stability of the cells as well as membrane-bound organelles. Membranes also play vital roles in cell-to-cell and intracellular communication.
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