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Updated: Feb 21, 2026

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
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Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

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炎症性および腫瘍性経路を標的とする:サイクロオキシゲネーゼ-2,表皮成長因子受容体,およびピラゾロン誘導体によるp38ミトゲン活性化タンパク質キナーゼ抑制

Sevde Nur Biltekin Kaleli1,2, Evren Önay Uçar3, Zafer Şahin4,5

  • 1Department of Pharmaceutical Microbiology, School of Pharmacy, Medipol University, Istanbul, Türkiye.

ChemMedChem
|February 20, 2026
PubMed
まとめ

8種類の新しいピラゾロン誘導体が合成され,抗炎症性および抗がん性について評価されました. 化合物7と8は,サイクロオキシゲネーゼ-2 (COX-2) を選択的に抑制し,抗炎症および抗がん剤としての潜在性を示しています.

キーワード:
抗がん剤は,抗がん剤として用いられる.抗炎症薬として使われています.エピダーマルの成長因子受容体p38 ミトゲン活性化タンパク質キナーゼピラゾロネロン (Pyrazolone) は,ピラゾロネール (Pyrazolone) と呼ばれています.

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