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Updated: Jul 3, 2026

An In Vitro Dormancy Model of Estrogen-sensitive Breast Cancer in the Bone Marrow: A Tool for Molecular Mechanism Studies and Hypothesis Generation
08:48

An In Vitro Dormancy Model of Estrogen-sensitive Breast Cancer in the Bone Marrow: A Tool for Molecular Mechanism Studies and Hypothesis Generation

Published on: June 30, 2015

NRG4は,ERBB4-YAP1媒介によるMMPのダウンレギュレーションにより,乳がんの転移を抑制する

Saijun Wang1, Mingwei Guo2, Lingyun Xu3

  • 1Department of Gastrointestinal Surgery, Changzhou Medical Center, The Third Affiliated Hospital of Nanjing Medical University, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Nanjing Medical University, Changzhou, Jiangsu 213000, China.

Genes & diseases
|February 20, 2026
PubMed
まとめ

肥満は乳がんの拡大を悪化させる. 脂肪組織からの神経ルギン4 (NRG4) は,ERBB4-YAP1経路を遮断することによって転移抑制剤として作用し,潜在的な治療標的を提供します.

キーワード:
乳がん 乳がんは乳がんです.エピテリアメセンスキマの移行マトリックスメタルプロテインアースの変異ニューレグリン 4 4YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP YAP

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Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells06:54

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Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells09:37

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

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