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Updated: May 5, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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ヒト炭酸水素酸塩のイソフォーム選択的阻害のための戦略としてのステロイド性A/B環融合

Jiří Brynda1, Anita Kiss1, Klára Pospíšilová1

  • 1Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences Prague Czech Republic kudova@uochb.cas.cz.

RSC advances
|February 20, 2026
PubMed
まとめ

ステロイド化合物は,炭酸アンヒドラゼ (CA) 阻害剤として有望であり,特に癌に関連したCA IXを標的としています. エストラ-1,3,5(10) -トリエンやΔ5ステロイドのような特定の誘導体は,抗癌薬の開発の可能性を選択的に抑制します.

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Stereoisomerism of Cyclic Compounds

In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
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