関連する実験動画

Updated: Jul 2, 2026

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
11:37

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

ポリソルバートが,リン酸二酸化アミド酸モルフォリノオリゴヌクレオチド構造の分子および熱力学的性質に及ぼす影響

Evgenii Kliuchnikov1, Daniel Pierson2, Ying Chou1

  • 1Department of Chemistry, University of Massachusetts, Lowell, MA 01854, USA.

Molecular therapy. Nucleic acids
|February 20, 2026
PubMed
まとめ

Polysorbatesのような表面活性物質は,フォスフォロダイアミド酸モルフォリノオリゴヌクレオチド (PMOs) に結合することによって,それらを安定させます. この相互作用は,PMOの本質的なRNAのような構造を破壊することなく,PMOの展開を防止し,治療設計を支援します.

キーワード:
CDスペクトロスコーピーは,CDスペクトロスコーピーを用います.MT:オリゴヌクレオチド:治療法と応用PMO-表面活性物質の相互作用とエネルギーオールアトムMDシミュレーション計算機による分子モデリングphosphorodiamidate morpholino オリゴーマーについてポリソルベート20 20ポリソルベート80 80表面張力 表面張力 表面張力 表面張力 表面張力表面活性剤は,表面活性剤として使用されます.

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