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Updated: Feb 22, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

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肝硬変におけるPBPKモデリングのための包括的な病理生理学リポジトリ:継続的な疾患の進行と集団の変動を定量化する

Annika R P Schneider1,2, Vanessa Baier1,3, Jan-Frederik Schlender2,4

  • 1Institute of Applied Microbiology - iAMB, Aachen Biology and Biotechnology - ABBt, RWTH Aachen University, Aachen, Germany.

CPT: pharmacometrics & systems pharmacology
|February 20, 2026
PubMed
まとめ

この研究では,肝硬変患者の生理学的変化の包括的なリポジトリを開発しました. このリソースは,この複雑な患者集団のための薬剤開発と臨床試験設計を改善し,薬剤動力学 (PK) モデリングを強化します.

キーワード:
チャイルド・ピュー・スコアです.PBPKモデリング肝臓機能不全 肝臓機能不全肝硬変 (肝硬変) についてファルマコキネティクス 薬理学

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