腎臓移植患者におけるヘルペス・ゾスターの調査:単一センター研究
Kei Sakurabayashi1, Masaki Muramatsu1, Yoshihiro Itabashi1
1Department of Nephrology, Faculty of Medicine, Toho University, Tokyo, Japan.
まとめ
腎臓移植後のヘルペス・ゾスター (シングル) は一般的であり,患者の15.7%に感染しています. 危険因子には,腎臓機能の低下と強い免疫抑制が含まれており,若い成人でもそうである.
科学分野:
- ネフロロジーはネフロロジーを用います.
- 感染症 感染症は感染症です.
- 免疫学 免疫学とは
背景:
- ハーペス・ゾスター (shingles) は,腎臓移植後の重大な合併症である.
- 発症率とリスク要因を理解することは,患者の管理に極めて重要です.
研究 の 目的:
- 成人腎臓移植患者のヘルペス・ゾスターの発生率を決定する.
- ゾスターヘルペスの発症と拡散に関連する独立した危険因子を特定する.
主な方法:
- 2013年4月から2023年3月までの714人の成人腎臓移植受験者の遡及的レビュー.
- 1000人年あたりの発生率の計算.
- リスク要因を特定するための多変数ロジスティック回帰.
主要な成果:
- ハーペス・ゾスターは患者の15.7%で発生し,1000人年当たり22.1%の発生率を示した.
- 特定された独立リスク要因は,推定グルメルフィルタレーション率の低下とウサギの抗リンパ球抗体使用でした.
- 拡散した症例は,抗リンパ球抗体使用でより頻繁に発生しました.
結論:
- ハーペス・ゾスターは,若い成人を含む腎臓移植受容者の一般的な合併症です.
- 免疫抑制の増大と腎機能障害は,より高いリスクと潜在的拡散と関連しています.
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