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Updated: Feb 22, 2026

Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes
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コバレンツから超分子へ: リソソームを標的とするキメラをモジュラーで調節可能な近接制御を通じて再考する

Nan Wang1, Xiaoran Wang1, Zhengyu Jiang1

  • 1Jiangsu Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, China.

Chemistry (Weinheim an der Bergstrasse, Germany)
|February 20, 2026
PubMed
まとめ

この研究は,化学生物学における硬直な共振結合体に対するダイナミックな代替手段として,超分子宿主-ゲスト相互作用を紹介する. このアプローチにより,特にライソソームターゲティングにおいて,相互作用に対する調整可能な制御を備えた適応性のある分子システムが可能になります.

キーワード:
二機能分子である分子である.ホスト ゲスト システム誘導された近接性.超分子集合体である.

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