韓国のコミュニティ製薬店における薬物療法の複雑性と患者報告による薬剤有害事象:横断的研究
1College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Republic of Korea.
Pharmacy (Basel, Switzerland)
|February 20, 2026
まとめ
薬物療法の複雑さは,報告された薬剤有害事象 (ADEs) の減少と関連しています. 高齢者および複雑なレジメンの患者では,ADEsの報告が不足している可能性があり,検出を改善するために患者中心の戦略の必要性を強調しています.
科学分野:
- 薬理学 薬理学とは
- 患者の安全性について
- 医療サービス 研究 医療サービス
背景:
- 薬物療法の複雑さと,患者によって報告された薬物有害事象 (ADEs) の関係に関する証拠は限られている.
- この関連性を理解することは,コミュニティ薬局の環境で患者の安全性と薬剤管理を改善するために不可欠です.
研究 の 目的:
- コミュニティの薬局サービスを利用する成人の薬物療法の複雑さと患者によって報告されたADEsとの関連を調べる.
- 薬物療法の複雑さに影響を与える要因と,ADE報告の予測要因を特定する.
主な方法:
- 韓国のコミュニティ薬局で処方箋経験を持つ201人の成人を対象に横断調査が行われました.
- 収集されたデータには,医薬品レジメンの複雑性指数-韓国 (MRCI-K) のスコア,投与順守,ADE報告,併発症,ポリファーマシー,および人口統計が含まれています.
- 多変数回帰モデルは,ADE報告の複雑性の決定因子と予測因子を評価するために使用されました.
主要な成果:
- 参加者の半数以上 (50.2%) が,過去1ヶ月間に少なくとも1回のADEを報告しました.
- 多剤療法,併発症,多用量投与は,より複雑な治療法と関連していた.
- 高いMRCI-Kスコアと高齢化は,ADEを報告する確率が低いことと関連していた (OR = 0.95と0.98,それぞれ).
結論:
- 薬物療法の複雑性の増加と高齢化は,薬物の副作用の報告の減少と関連しています.
- これは,これらの患者グループにおけるADEsの潜在的認識不足を示唆しています.
- 患者中心の戦略は,複雑な薬物療法のレジメンを持つ個人の間でADEの識別を強化するために不可欠です.
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