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エストラディオルの皮膚下投与と肌内投与の比較,女性化性確定ホルモン療法の比較
Abby C Poage1, Jordan M Rowe1,2, Mary Beth A Dameron1
1University Health Truman Medical Center, Kansas City, MO 64108, USA.
Pharmacy (Basel, Switzerland)
|February 20, 2026
まとめ
皮膚下 (SC) と筋肉内 (IM) のエストラジオール投与は,トランスジェンダー患者で6ヶ月で治療レベルを達成する際に同様の有効性を示しました. 筋内注射は,探査分析において,より高いエストラジオール濃度に関連していた.
科学分野:
- エンドクリノロジー エンドクリノロジー
- ジェンダー・アファメーション・ケア
- 薬理学 薬理学とは
背景:
- エストラディオルの投与は,ジェンダーアファメーションホルモン療法において極めて重要です.
- 皮下 (SC) と筋肉内 (IM) 経路は,エストラジオルの投与のための一般的な方法です.
- エストラディオールの投与を最適化することで,治療効果と患者の安全性が確保されます.
研究 の 目的:
- 性別不一致または性差症の患者におけるSC対IMエストラジオール投与の有効性を比較する.
- エストラディオルの治療レベルが投与後6ヶ月で達成されたことを評価するために.
- エストラディオール濃度の違いと注射教育の影響について調べる.
主な方法:
- LGBTQ専門診療所の70人の成人の患者を対象とした遡及的なコホート研究.
- 2018年10月から2024年12月までのSC対IMエストラジオール投与の比較.
- プライマリエンドポイント:6ヶ月で治療用エストラジオール濃度;二次:3,6,9,12ヶ月で濃度,注射教育.
主要な成果:
- SCとIM群の間で6ヶ月で治療用エストラディオールレベルを達成する点で有意な差はありません.
- 探索的分析は,IM投与で測定されたエストラディオール濃度がより高いことを示した.
- 薬剤師主導の注射教育も評価された.
結論:
- SCおよびIMの両方のエストラディオール投与は,ジェンダー不一致性/性差症の治療レベルを達成するのに有効です.
- IMエストラディオールは,循環中の濃度の上昇につながる可能性があるため,さらなる調査が必要である.
- 個別化されたエストラディオール投与戦略は有益である可能性があります.
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