小児患者の血清25 (((OH) D濃度と臨床的特徴の関連性
Maria Nicolae1, Sorin Deacu2, Cristina Maria Mihai3
1Doctoral School, Faculty of General Medicine, "Ovidius" University, 900470 Constanta, Romania.
Reports (MDPI)
|February 20, 2026
まとめ
呼吸器感染症で入院した小児のビタミンDレベルが低いと,入院期間が長くなり,重症になる可能性が高くなります. 十分なビタミンDを摂取すると,小児の呼吸器感染症のアウトカムが改善される可能性があります.
科学分野:
- 小児医学は,小児科の医学である.
- 免疫学 免疫学とは
- 栄養科学とは,栄養科学である.
背景:
- ビタミンDは,免疫機能と炎症,特に呼吸器感染症において重要な役割を果たします.
- 栄養補給にもかかわらず,小児性D型低ビタミン症は子供に多く見られ,東欧における小児性呼吸器感染症の入院結果への影響に関するデータは限られている.
研究 の 目的:
- 急性呼吸器管感染症 (ARTI) の小児患者のビタミンD状態と入院の結果の関連性を調査する.
主な方法:
- ARTIのために入院した400人の小児科患者のコホートは,血清25(OH) Dレベルに基づいて,正常なビタミンD (NVD) と低ビタミンD (LVD) グループに分けられました.
- 連続変数のグループ間比較には,非パラメトリックの方法を使用した.
主要な成果:
- LVD群の子どもたちは, signicantly longer hospitalizations (4.68 days vs. 2.89 days) を経験し,臨床スコア,CRPレベル,そして酸素療法の必要性など,疾患の重度のマーカーが高くなった.
- LVDグループは,NVDグループ (平均47.60 ng/mL) に比べて,血清ビタミンD濃度 (平均21.63 ng/mL) が低いことを示した.
- 発熱はLVD群でより頻繁 (61.0%対32.0%) であり,血清25(OH) Dと入院期間と重症度の間には逆相関が認められた.
結論:
- 低血清25 ((OH) D濃度は,小児における急性呼吸器感染症の重症度増加と長期の入院に関連しています.
- これらの発見は,小児の呼吸器の健康のために十分なビタミンDレベルが重要であることを強調し,ビタミンD状態を最適化する潜在的な利点を示唆しています.
関連する概念動画
Pharmacokinetics in Pediatric Patients: Drug Distribution
354
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
354
Drug Dosing: Infants and Children
371
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
371
Chronic Kidney Disease II: Clinical Manifestations
758
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
758
Serum Studies: Renal Function Tests
478
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
478
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance
264
In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance...
264
Role of Skin in Vitamin D Synthesis
8.3K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
8.3K


