不良薬剤反応に関連する入院と不良薬剤事件とその関連が,高齢者の短期および長期の健康結果と関連している
Juliane Frydenlund1, David J Williams2, Frank Moriarty3
1Data Science Centre, School of Population Health, RCSI University of Medicine and Health Science, D02 YN77 Dublin, Ireland.
Geriatrics (Basel, Switzerland)
|February 20, 2026
まとめ
高齢者における薬物不良反応 (ADR) や薬物不良事件 (ADE) は,時間の経過とともに生活の質や医療訪問の変化に有意な影響を及ぼさなかった. しかし,ADEsは,より悪い長期的な健康結果と関連していた.
科学分野:
- ゲロントロジーはゲロントロジーの学科です.
- 医薬品監視 医薬品監視
- 医療サービス 研究 医療サービス
背景:
- 高齢者の健康上の結果に対する有害薬物反応 (ADR) と有害薬物イベント (ADE) の影響を調査する.
- ADRに関連する入院と,健康関連の生活の質 (HRQOL),機能的低下,およびA&E訪問の変化による健康関連の生活の質 (HRQOL),機能的低下,およびA&E訪問との間の関連を調べる.
- アイルランドの2つの前向きなコホート研究:ADAPT (N=230) とCPCR (N=605) を利用した.
研究 の 目的:
- ADRに関連した入院または初等医療におけるADEsが,HRQOLの縦断的な変化,機能的低下,および高齢者のA&E訪問と関連しているかどうかを判断する.
- 特定の健康上のアウトカムに対するADRとADEの短期的および長期的な影響を評価する.
- 年齢,性別,併発性,多用薬など,主要な混同要因を調整する.
主な方法:
- 展望的なコホート研究 (ADAPTとCPCR) ベースラインとフォローアップの健康結果のアンケート.
- ベースラインでのADR関連入院およびADEの評価.
- 多変数回帰分析 (線形,ロジスティック,オーダーナルロジスティック) で,ADR/ADEとHRQOLの変化,機能的衰退,およびA&E訪問の関連性を調べます.
主要な成果:
- 短期的に (3ヶ月),ADAPTコホートでは,ADR状態に関係なく,脆弱性が増加し,A&E訪問は減少しました.
- 長期 (24ヶ月) において,HRQOLは減少し,機能的低下とA&E訪問は,ADEとADE以外のグループの両方のCPCRコホートで増加しました.
- ADEを持つ個人は,ベースラインのHRQOLが低く,機能的低下がより顕著であったが,ADRまたはADEを経験することは,調整後,これらのアウトカムにおける時間の経過の変化と有意に関連していなかった.
結論:
- ADR群とADR群以外のグループでは,医療負担の短期的な有意な差異は観察されなかった.
- 薬剤による有害事象 (ADEs) は,高齢者の長期的な健康状態の悪化と関連していた.
- この研究は,特定のアウトカム測定値の時間経過の変化と有意な関連が欠如しているにもかかわらず,ADEsの長期的な影響を考慮する重要性を強調しています.
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