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Updated: Feb 22, 2026

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
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PI3Kδ-Foxo1-FasL信号増幅ループは,CD4+T細胞の信号伝達と分化を再接続する

Dominic P Golec1,2, Pedro H Gazzinelli-Guimaraes3, Daniel Chauss4

  • 1Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA.

The Journal of experimental medicine
|February 20, 2026
PubMed
まとめ

PI3Kδ変異の活性化により,Tヘルパー細胞の分化が妨げられ,免疫機能の欠陥が生じます. FasLを阻害すると,T細胞機能が正常化し,Fas-FasLシグナル伝達がPI3Kδ主導の免疫不調の重要な要因であることを明らかにした.

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