EGFRキナーゼドメインのカルボキシ末端にある自己結合ペプチドの構造ベースの同定、リン酸化、環化、およびエンジニアリング:ダイナミクスシミュレーション、エネルギー計算、および蛍光分析の統合
Jingjing Chen1, Tianyu Wang1, Lijuan Shi2
1Department of Radiology, Liyang People's Hospital, Affiliated Liyang People's Hospital of Kangda College of Nanjing Medical University, 213300, Liyang, China.
European biophysics journal : EBJ
|February 20, 2026
まとめ
No abstract available in PubMed .
さらに関連する動画
10:33Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
Published on: October 26, 2015
11.9K
11:23Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein
Published on: June 30, 2019
6.7K
関連する概念動画
Receptor Tyrosine Kinases
19.7K
Receptor tyrosine kinases or RTKs are membrane-bound receptors that phosphorylate specific tyrosine on protein substrates. RTKs regulate cellular growth, differentiation, survival, and migration. They contain an extracellular ligand binding domain, a transmembrane domain, and a cytosolic tail with intrinsic kinase activity. Several extracellular signaling molecules activate RTKs in one or more ways and relay the signal downstream. Ligands such as platelet-derived growth factor (PDGF) or...
19.7K
Protein Kinases and Phosphatases
15.3K
Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
15.3K
