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関連する概念動画

Golgi Matrix Proteins01:12

Golgi Matrix Proteins

2.5K
Golgi matrix proteins are a group of highly dynamic proteins that maintain the stacked structure of Golgi. These proteins adapt to rapid morphological changes of the Golgi during the cell cycle. During cell division, mild proteolysis removes these connections resulting in Golgi unstacking. In The daughter cells, these proteins help reassemble the unstacked Golgi.
One of the first identified Golgi matrix proteins was GM130, a rod-like protein located in the cis-Golgi. Subsequently, many Golgi...
2.5K
Golgi Apparatus01:49

Golgi Apparatus

105.3K
As they leave the Endoplasmic Reticulum (ER), properly folded and assembled proteins are selectively packaged into vesicles. These vesicles are transported by microtubule-based motor proteins and fuse together to form vesicular tubular clusters, subsequently arriving at the Golgi apparatus, a eukaryotic endomembrane organelle that often has a distinctive ribbon-like appearance.
105.3K
Golgi Apparatus01:09

Golgi Apparatus

22.4K
Properly folded and assembled proteins are selectively packaged into vesicles that exit the ER. Motor proteins transport these vesicles to the Golgi apparatus for adding modifications that make these proteins functional at their destination.
The Golgi apparatus is a eukaryotic organelle that has a distinctive ribbon-like appearance. It is a primary sorting and dispatch station for cargo arriving from the ER. Newly arriving vesicles enter the cis face of the Golgi, closest to the ER, and are...
22.4K
Coat Assembly and GTPases01:33

Coat Assembly and GTPases

4.5K
Vesicles incorporate different coat protein subunits in different cell locations, which changes the properties of the coat, such as the shape and geometry of the transport vesicles. Thus, vesicle coat proteins also play a significant role in cargo selection.
Coat assembly depends on the local availability of phosphatidylinositol phosphates or PIPs and GTP-binding proteins. Adaptor proteins, which link the coat proteins to the membrane, bind to these PIPs and play a crucial role in controlling...
4.5K
GPI Anchoring of Proteins in the ER Membrane01:29

GPI Anchoring of Proteins in the ER Membrane

5.6K
GPI-anchoring is a post-translational, reversible protein modification that is ubiquitous in eukaryotes. Such proteins are primarily present on the exoplasmic leaflet of the plasma membrane.
GPI-anchor structure
A sequence of 11 enzymatic reactions results in the synthesis of the complete GPI anchor consisting of a hydrophobic and a hydrophilic portion. The hydrophobic portion comprises phosphatidylinositol, while the hydrophilic part comprises polar groups like phosphoethanolamine,...
5.6K
Transport Across the Golgi01:26

Transport Across the Golgi

6.3K
While it is unclear how molecules move between adjacent Golgi cisternae, it is apparent that the molecules move from cis- cisterna, the entry face, to the trans- cisterna, the exit face. Experiments initially suggested vesicles that bud from one cisterna and fuse with the next cisterna to transport proteins between the cisternae. This vesicular transport model describes the Golgi apparatus as a relatively static structure with a unique enzyme composition in each cisterna. Molecules are...
6.3K

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Updated: Feb 22, 2026

Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass
13:08

Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass

Published on: August 10, 2017

11.4K

ゴルギの生理学におけるGARP複合体

Amrita Khakurel1, Walter S Aragon-Ramirez1, Vladimir V Lupashin2

  • 1Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Sub-cellular biochemistry
|February 20, 2026
PubMed
まとめ
この要約は機械生成です。

ゴルジ関連逆行性タンパク質 (GARP) 複合体は,エンドソームからゴルジへの膀輸送に不可欠です. GARPを理解する

キーワード:
エンドソーム-TGN逆行性トラフィキングガープ (GARP) とはグライコシライゼーションによる.人身売買の機械膀結合は,膀結合というものです.

さらに関連する動画

Analysis of Endocytic Uptake and Retrograde Transport to the Trans-Golgi Network Using Functionalized Nanobodies in Cultured Cells
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Analysis of Endocytic Uptake and Retrograde Transport to the Trans-Golgi Network Using Functionalized Nanobodies in Cultured Cells

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Visualization of G3BP Stress Granules Dynamics in Live Primary Cells
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Visualization of G3BP Stress Granules Dynamics in Live Primary Cells

Published on: May 21, 2014

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関連する実験動画

Last Updated: Feb 22, 2026

Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass
13:08

Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass

Published on: August 10, 2017

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Analysis of Endocytic Uptake and Retrograde Transport to the Trans-Golgi Network Using Functionalized Nanobodies in Cultured Cells
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Analysis of Endocytic Uptake and Retrograde Transport to the Trans-Golgi Network Using Functionalized Nanobodies in Cultured Cells

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Visualization of G3BP Stress Granules Dynamics in Live Primary Cells
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Visualization of G3BP Stress Granules Dynamics in Live Primary Cells

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科学分野:

  • 細胞生物学 細胞生物学
  • 分子生物学は分子生物学である.
  • 遺伝学 遺伝学とは

背景:

  • CATCHRファミリーの一部であるゴルジ関連逆行性タンパク質 (GARP) 複合体は,エンドソームからトランス-ゴルジネットワーク (TGN) への膀結合を媒介する.
  • GARPは,ヒドローラースの分類と膜タンパク質のリサイクルに不可欠ですが,その正確なメカニズム,パートナー,密輸中間物質は十分に研究されていません.
  • GARPに依存する経路は,神経学的疾患に関連した変異を持つタンパク質,ヒドロラーゼ受容体,および病原菌のリサイクルによって使用されます.

研究 の 目的:

  • GARP複合体の構造,機能,相互作用に関する現在の知識をレビューする.
  • GARP変異の影響とヒトの病理学との関連を要約する.
  • GARPに依存する人身売買のあまり研究されていない側面を強調する.

主な方法:

  • GARP複合体に関する既存の研究の文献レビュー.
  • タンパク質分類と膜リサイクルにおけるGARPの役割に関する研究の分析.
  • GARP変異および人間およびモデル生物における関連する神経学的疾患に関するデータの収集.

主要な成果:

  • GARP複合体は,エンドソームからTGNへの逆行性トランスファーキングで機能する.
  • GARPに依存する輸送は,様々な細胞プロセスに不可欠であり,病原菌によって利用されます.
  • GARPサブユニットの変異は,神経疾患に関与しているが,そのメカニズムは不明である.

結論:

  • GARP複合体は,細胞の密輸経路において重要な役割を果たします.
  • GARPの正確な分子機構と疾患関連を明らかにするためにさらなる研究が必要です.
  • GARPを理解することは,正常な細胞機能と神経疾患の病原性の両方についての洞察にとって不可欠です.