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Updated: Feb 22, 2026

Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity
09:32

Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity

Published on: October 17, 2025

571

ペリプロジェニンは,FOXO1/P53シグナル伝達経路を活性化することにより,細胞老化を誘導することにより,肝癌発症を抑制します

Peizhen Wang1,2, Jianyu Zhu3, Wen Li1,2

  • 1Department of Medical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Phytotherapy research : PTR
|February 20, 2026
PubMed
まとめ

皮質 (Cortex Periplocae) の化合物であるペリプロジェニンは,細胞老化を誘発することによって,肝細胞癌 (HCC) の成長を効果的に抑制します. FOXO1/P53経路を活性化して,肝がんの新たな治療法となる可能性がある.

キーワード:
FOXO1は,FOXO1という名前で,FOXO1はFOXO1という名前です.細胞の老化 細胞の老化肝細胞性癌 (HCC) は,肝細胞性癌 (HCC) と呼ばれています.ペリプルゲニン (ペリプルゲニン) とはトランスクリプトロミクス transcriptomics

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