COVID-19に関連した嗅覚機能不全と古典的なポストウイルス性嗅覚機能不全の比較分析:マルチセンターの遡及研究
T Miwa1, K Tsuzuki2, I Suzaki3
1Department of Otorhinolaryngology, Kanazawa Medical University, Kahoku, Ishikawa, Japan.
Rhinology
|February 20, 2026
まとめ
COVID-19 (COVID-19-OD) の嗅覚機能不全 (OD) は,後ウイルス性OD (PVOD) と異なり,より若い患者と異なる症状を示します. COVID-19-ODの重症度はより軽く,ウイルスの変種によって変化し,生物学的違いを示唆しています.
科学分野:
- 耳鼻喉科 (Otorhinolaryngology) は,耳鼻喉科 (Otorhinolaryngology) を専門とする医療機関である.
- 感染症 感染症は感染症です.
- 神経学 神経学とは
背景:
- 嗅覚機能障害 (OD) は,一般的なCOVID-19の症状ですが,その特徴は従来のポストウイルス性OD (PVOD) とは異なります.
- COVID-19-ODの特徴もウイルスのサブタイプによって異なるため,比較分析が必要である.
研究 の 目的:
- COVID-19-ODとPVODの臨床的特徴と嗅覚機能を比較する.
- COVID-19の変種間のOD特性の違いを調査する.
主な方法:
- 269人のCOVID-19-OD患者 (2020-2022) と380人のPVOD患者 (2017-2019) を比較したマルチセンター遡及研究.
- 分析には,患者の人口統計,嗅覚裂け目の状態,および医療記録からの嗅覚機能が含まれていました.
主要な成果:
- COVID-19-OD患者は,PVOD患者よりも若く,嗅覚裂縫の阻害が高く,パロスミア/ファントスミアが多かった.
- 年齢調整後でも,COVID-19-ODではODの重度が軽かった.
- オミクロン以前のCOVID-19-OD症例は,オミクロン症例よりも若く,パロスミア/ファントスミアの割合が高かった.
結論:
- COVID-19-ODとPVODは,臨床表現とODの病理生理学において有意な違いを示しています.
- 変種間のCOVID-19-OD内部の変異は,嗅覚機能不全に影響を与える潜在的ウイルス生物学的違いを示唆しています.
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