関連する実験動画

Updated: Feb 22, 2026

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
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A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

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カーバ-NAD結合は,形状の可塑性を再構築し,長距離アロステルネットワークの再配線によってSIR2を活性化します

Bao-Dan Zhang1,2,3, De-Rui Zhao1,2,3, Meng-Ting Liu1,2

  • 1College of Agriculture and Biological Science, Dali University, Dali, China.

PLoS computational biology
|February 20, 2026
PubMed
まとめ

この研究では,酵母SIR2へのコファクターの結合が"コアロックと周辺放出"のダイナミックモードを誘発し,新しいアロステルカスケードと長寿活性化剤の薬剤ポケットを発見する方法が明らかにされています.

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