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Updated: Feb 22, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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人間のlncRNARMRPは,DEAD-boxヘリカーズと相互作用し,ミトコンドリア機能を調節する

Higor Sette Pereira1, Jason Luddu1, Govardhan Reddy Veerareddygari1

  • 1Alberta RNA Research and Training Institute, Department of Chemistry and Biochemistry, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada.

Proceedings of the National Academy of Sciences of the United States of America
|February 20, 2026
PubMed
まとめ

長い非コーディングRNARMRPは,構造的な柔軟性を示し,RNAヘリコゼと相互作用することにより,ミトコンドリアの健康を調節する. このIncRNAは

キーワード:
DEAD-boxヘリカーゼは,デッドボックスヘリカーゼとRMRPRPは,RMRPに設定されています.ロング・ノンコーディングRNAミトコンドリアの機能

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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