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Updated: Feb 22, 2026

Capturing Common Fragile Site Breaks by Native γH2A.X ChIP
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ヘリカースのヘミジゴスな喪失は,ゲノム不安定性と癌の発症を促進する

Karolin Voßgröne1, Francesco Favero1,2, Krushanka Kashyap1

  • 1Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen 2200 N, Denmark.

Science advances
|February 20, 2026
PubMed
まとめ

癌の変異は,DNA処理に不可欠な酵素であるヘリカーゼを頻繁に変化させる. これらの変異は,ゲノム不安定性とDNA修復の欠陥を誘発し,ヘルキースを主要ながん誘発因子として強調しています.

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