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Updated: Feb 22, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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遺伝性出血性テランジエクトアシアにおけるポマリドミドに対する臨床反応に関連する特徴

Hanny Al-Samkari1, Sonia Thomas2, Derek Joseph Marsh3

  • 1Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States.

Blood advances
|February 20, 2026
PubMed
まとめ

ポマリドミドは,遺伝性出血性遠隔膜症 (HHT) の出血を効果的に治療します. ベースラインより高いエピスタキシス重症度スコア (ESS) と抗線維解剤の使用は,よりよい応答を予測しますが,高齢とACVRL1変異は,より堅固な結果を示唆します.

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