腸内不妊症に関連する不妊症:プロバイオティクスとシンバイオティクスのサプリメントの有効性
Samaneh Abdolmohammadi-Vahid1, Vida Ebrahimi1, Mohammad Sadegh Soltani-Zangbar1
1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Journal of reproductive immunology
|February 20, 2026
まとめ
プロバイオティクスとシンバイオティクスは,腸の健康と代謝機能を改善することによって不妊症に対する希望を示しています. シンバイオティクスは効果を高める可能性があるが,妊娠の結果についてはさらなる研究が必要である.
科学分野:
- 生殖内分泌学 生殖内分泌学
- マイクロバイオーム研究
- 免疫学 免疫学とは
背景:
- 不妊症は,世界のカップルの17%に影響し,ますます腸内不妊症と免疫代謝の不均衡に関連しています.
- 腸内微生物群は,インスリン感受性および生殖ホルモンを調節する上で重要な役割を果たします.
- 腸内細菌の不均衡は,多発性卵巣症候群 (PCOS) を含む様々な不妊要因と関連しています.
研究 の 目的:
- 不妊症の管理におけるプロバイオティクスとシンバイオティクスの役割を調査する.
- 不妊に関連するパラメータを改善する際のプロバイオティクスの有効性をシンバイオティクスと比較する.
- 不妊治療のための微生物群ベースの介入の可能性を評価する.
主な方法:
- 不妊症におけるプロバイオティクス (ラクトバシルス,ビフィドバクテリウム) とシンバイオティクスに関する現在の研究のレビュー.
- 腸内細菌,インスリン感受性,生殖ホルモン,炎症への影響を調べた研究の分析.
- 妊娠や生育率などの生殖結果に関する証拠の評価.
主要な成果:
- プロバイオティクスは,腸のバランスを回復し,インスリン感受性を改善し,生殖ホルモンを調節することができます.
- シンバイオティクスは,微生物の多様性,短鎖脂肪酸の産生,免疫内分泌機能を強化する.
- シンバイオティクスは,特にPCOS患者の不妊症の代謝,ホルモン,炎症的な側面に対して,プロバイオティクスよりも有効である可能性があります.
結論:
- プロバイオティクスとシンバイオティクスは,不妊症管理に有利な安全性プロファイルを持っています.
- シンバイオティクスは,不妊症に関連する主要なパラメータの改善において,プロバイオティクスよりも大きな有効性を持つ可能性があることを示しています.
- 決定的な生殖的結果のための共生性の優位性を確認するために,パーソナライズされた,微生物群ベースの不妊症戦略をサポートするために,さらなる研究が必要です.
さらに関連する動画
関連する概念動画
Drugs for Treatment of Constipation-Predominant IBS
943
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
943
Drugs for Treatment of Diarrhea-Predominant IBS
767
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
767
Infertility in Females
4.9K
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
4.9K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
950
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
950
Infertility in Males
608
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
608
Inflammatory Bowel Disease IV: Pharmacological Management
832
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
832


