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Updated: Feb 22, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
07:16

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

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GABAA受容体標的リガンドにおける最近の進歩

Yuanyan Zuo1, Yilan Zhao2, Genyan Liu1

  • 1Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, 430205, PR China.

European journal of medicinal chemistry
|February 20, 2026
PubMed
まとめ

γ-アミノバター酸A型 (GABAA) 受容体は,脳抑制の鍵となっている. クリオ・エムによる新しい構造的洞察は,神経精神疾患に対する標的薬の開発を導いています.

キーワード:
アロステリック・モジュレータクリオ・エム構造は,冷凍-エム構造である.ゲーバ (GABA) 受容体 (A) について神経精神疾患 神経精神疾患構造ベースの薬物設計亜型選択性 亜型選択性とは

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Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors07:51

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Using an α-Bungarotoxin Binding Site Tag to Study GABA A Receptor Membrane Localization and Trafficking11:57

Using an α-Bungarotoxin Binding Site Tag to Study GABA A Receptor Membrane Localization and Trafficking

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