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Updated: Feb 22, 2026

In Vitro Analysis of E3 Ubiquitin Ligase Function
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Published on: May 14, 2021

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解読E1-E2特異性:UBA6がユビキチン結合のためのBIRC6を優先させる方法

Jiajia Wei1, Chao Xu1

  • 1MOE Key Laboratory for Cellular Dynamics, Hefei National Laboratory for Physical Sciences at the Microscale, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

Cell chemical biology
|February 20, 2026
PubMed
まとめ

ユビキチン結合酵素BIRC6は,ユビキチン活性化酵素UBA6と特異的に結合する. この研究は,この特異性とチオエステルスイッチのメカニズムを明らかにし,E1-E2酵素の階層を明確にします.

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