関連する実験動画

Updated: Feb 22, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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規制の構造的メカニズムと薬物発見の機会のCDKの多様性

Rhianna J Rowland1, Martin E M Noble1, Jane A Endicott1

  • 1Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

Trends in biochemical sciences
|February 20, 2026
PubMed
まとめ

サイクリン依存キナーゼ (CDK) は細胞サイクルと遺伝子転写を調節する. 最近の構造研究は,CDKの調節に関する新しい洞察を明らかにし,より選択的ながん治療の開発の可能性を提供します.

キーワード:
CDK CDKとはX線結晶グラフィーです.低温電子顕微鏡による冷凍電子顕微鏡サイクリン (Cycline) とは短い線形モチーフです.構造ベースの薬物設計

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Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay12:26

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Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
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The cell cycle is a series of events leading to DNA duplication followed by the division of cell content to form two daughter cells. The cell cycle progresses in four stages—the cell increases in size (gap 1 or G1-phase), duplicates its DNA (synthesis or S-phase), prepares to divide (gap 2 or G2-phase), and divides (mitosis or M-phase).
Two states at the origin of replication
In eukaryotes, the initiation of replication occurs at many sites on the chromosomes, called the origins of...
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