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Updated: Feb 22, 2026

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture
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EZH2とDNAメチレーションの交差は,神経内分泌性前立腺がんの系統の可塑性を媒介する

Richa Singh1, Varadha Balaji Venkadakrishnan2,3,4, Eddie Imada1

  • 1Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.

Nature communications
|February 20, 2026
PubMed
まとめ

DNAメチル化とゼステホモログ2 (EZH2) の強化剤により,前立腺がんの血統の可塑性をエピジェネティックに制御する. 彼らの相互作用は,神経内分泌前立腺がん (NEPC) の遺伝子発現を決定し,新しい治療標的を明らかにします.

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