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Updated: Feb 22, 2026

Author Spotlight: Integrating BRET-Based Assays and Rare Mutation Analysis to Decipher RAF Kinase Regulation in Live Cells
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Author Spotlight: Integrating BRET-Based Assays and Rare Mutation Analysis to Decipher RAF Kinase Regulation in Live Cells

Published on: March 1, 2024

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ベータアレスティン1媒介による Src SH3ドメインによる Src活性化のメカニズムが,冷凍電子顕微鏡で明らかにされました

Natalia Pakharukova1,2, Brittany N Thomas1,2, Harsh Bansia3,4

  • 1Department of Medicine, Duke University Medical Center, Durham, NC, 27710, USA.

Nature communications
|February 20, 2026
PubMed
まとめ

ベータアレスティン (βARRS) は,Srcキナーゼと結合し,活性化することによって,シグナル伝達を積極的に調節する. この研究は,この相互作用の構造的基礎を明らかにし,βarr1が特定の結合部位を通じて直接Src活性化を誘発することを示しています.

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