関連する実験動画

Updated: Feb 22, 2026

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
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UPLC-MS/MSメソッドの開発と,ラットにおけるレゴラフェニブの薬理学分析のためのその応用

Filip Otto1, Viktoriia Propisnova2, Hanna Urjasz1

  • 1Department of Clinical Pharmacy and Biopharmacy, Poznań University of Medical Sciences, Rokietnicka 3, Poznań, 60-806, Poland.

Scientific reports
|February 20, 2026
PubMed
まとめ

この研究では,レゴラフェニブ (REG) とその代謝産物 (metabolites) を定量化するために,UPLC-MS/MSで検証された方法を開発しました. トラメチニブ (TRA) と併用すると,ラットにおけるREG全身曝露が著しく増加した.

キーワード:
N-デメチルレゴラフェニブN-オキシードファルマコキネティクスレゴラフェニブ (レゴラフェニブ) はレゴラフェニブ (レゴラフェニブ) とはレゴラフェニブN酸化物トラメチニブ (Trametinib) とは,トラメチニブ (Trametinib) とは,トラメチニブ (Trametinib) とは,トラメチニブ (Trametinib) とは,トラメチニブ (Trametinib) とは,トラメチニブ (Trametinib) とは,UPLC-MS/MS/MSは,UPLC-MS/MSと一致している.

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