炎症性腸疾患の患者におけるE型肝炎感染:体系的なレビューとメタ解析
Dionysios Kogias1, Georgios Kouklakis1, Vasileios Papadopoulos2
1First Department of Internal Medicine, Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
Journal of viral hepatitis
|February 20, 2026
まとめ
肝炎Eウイルス (HEV) 感染症は,一般の人々と同様に,炎症性腸疾患 (IBD) の患者で一般的です. しかし,重度の免疫抑制はリスクを高め,肝臓酵素値が上昇したIBD患者のHEV検査が必要になります.
科学分野:
- 胃腸内科 胃腸内科
- 肝臓病理学 肝臓病理学
- 感染症 感染症は感染症です.
背景:
- 機会性感染症は,炎症性腸疾患 (IBD) で,特に免疫抑制療法では,懸念が高まっている.
- 肝炎Eウイルス (HEV) は,世界中でウイルス性肝炎の重要な原因ですが,IBDにおけるその役割はよく定義されていません.
研究 の 目的:
- HEV感染とIBDの関連性を体系的にレビューし,メタ分析する.
- IBD患者におけるHEV感染マーカーの有病率を決定し,一般人口と比較する.
主な方法:
- 2025年5月まで,PubMed/MEDLINEとGoogle Scholarで包括的な文献検索が行われました.
- 1316人のIBD患者を対象とした6つの研究では,HEV感染マーカー (anti-HEV IgG,IgM,HEV-RNA) を評価した.
- 研究の質は,Joanna Briggs Instituteの分析的横断研究チェックリストを使用して評価されました.
主要な成果:
- IBD患者における抗HEV IgGの総流行率は13.5% (異質) であった.
- 抗HEV IgMとHEV-RNAの陽性率は低い (それぞれ1.9%と0.03%).
- IBD患者におけるHEVの罹患率は,一般の人々と同様のものであったが,免疫不全の移植受容者および強度の免疫抑制を有する患者では高かった.
結論:
- IBD患者におけるHEVの罹患率は,一般的には一般人口を反映しています.
- IBD患者の原因不明の肝臓酵素上昇は,HEV感染の検討を正当化します.
- IBDにおける重度の免疫抑制は,持続的なHEV感染および合併症に対する感受性を高め,通常の検査を提案する可能性があります.
キーワード:
クローン病 (Crohn's disease) とは,クローン病 (Crohn's disease) とは,クローン病 (Crohn's disease) とは,クローン病 (Crohn's disease) とは,クローン病 (Crohn's disease) とは,クローン病 (Crohn's disease) とは,クローン病 (Crohn's disease) とは,クローン病 (Crohn's disease) とは,クローン病 (Crohn's disease) とは,クローン病 (Crohn's disease) とは,クローン病 (Crohn's disease) とはE型肝炎 (E型肝炎) について免疫抑制は免疫を抑制する.炎症性腸疾患とは潰瘍性大腸炎について
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