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Updated: Feb 22, 2026

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
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Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

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キュマリン強化チアゾールハイブリッドは,ダブル抗がん剤と抗菌剤として使用されています

Islam K Matar1,2, Magdi E A Zaki3, Zeinab A Muhammad4

  • 1Department of Chemistry, Saint Mary's University, Halifax, Nova Scotia, Canada.

Chemical biology & drug design
|February 21, 2026
PubMed
まとめ

新型チアゾル-ヒドラゾノ-キュマリンは,耐性細菌に対する強力な抗菌作用と選択的な抗がん効果を示しています. これらの化合物はトポイソメラーゼ酵素を標的にし,がん患者の感染症の治療に有望である.

キーワード:
DNAギラゼB阻害剤は,DNAギラゼB阻害剤として使用されています.抗菌作用がある.抗がん剤は,抗がん剤として用いられる.クマリン誘導体のクマリン誘導体は,トポイソメラーゼII阻害剤について

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