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Updated: Feb 22, 2026

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

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スーパーエンハンサー駆動のSOX4/SMAD3は,リンパ脂代謝を調節することで,白血病の進行を加速させるための中介膜リモデリングを行います

Enzhe Lou1,2, Peilong Lai3, Guanjie Peng4

  • 1Sino-French Hoffmann Institute, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|February 21, 2026
PubMed
まとめ

新しい研究では,SOX4とSMAD3が,進行性の慢性髄膜白血病 (CML) の爆破期における重要な要因であると特定されています. これらの要因をベムセンチニブで標的にすることは,この攻撃的な白血病の治療に有望であることが示されています.

キーワード:
爆破段階は爆破段階である.慢性骨髄性白血病 (CML) とはスーパーエンハンスター スーパーエンハンスターターゲットを絞った治療法トランスクリプション・ファクターは,

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